Sinapic Acid Release at the Cell Level by Incorporation into Nanoparticles: Experimental Evidence Using Biomembrane Models

Sinapic acid (SA), belonging to the phenylpropanoid family, and its derivatives are secondary metabolites found in plant kingdom. In recent years, they have drawn attention because of their various biological activities, including neuroprotective effects. this study, SA was incorporated into two different nanoparticle systems, solid lipid nanoparticles (SLN) nanostructured carriers (NLC). The influence concentrations on systems evaluated. It studied efficacy release active ingredient at cell level through use models membranes represented by multilamellar vesicles (MLV) dimyristoylphosphatidylcholine (DMPC) conducting kinetic studies placing contact SLN NLC, both unloaded loaded with amounts SA, same membrane model. Differential scanning calorimetry (DSC) used for these studies. results indicated a distribution within that NLC able incorporate inside structure